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By Richard A. Goldsby, Thomas J. Kindt, Janis Kuby

The new version of the acclaimed bestseller, consistently praised for supplying innovative fabric within the context of landmark experiments, in a pupil pleasant structure outfitted on pedagogy no longer frequently present in immunology texts.

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The time period superfamily is used to indicate proteins whose corresponding genes derived from a standard primordial gene encoding the fundamental area constitution. those genes have developed independently and don't percentage genetic linkage or functionality. the subsequent proteins, as well as the immunoglobulins themselves, are consultant participants of the immunoglobulin superfamily (Figure 4-20): γ γ β γ γ CD89 seem at the plasma membrane as cell-surface antigens and, as indicated within the determine, many were assigned CD designations (for clusters of differentiation; see Appendix). [Adapted from M. Daeron, 1999, within the Antibodies, vol. five, p. fifty three. Edited by way of M. Zanetti and J. D. Capra. ] ■ Ig-␣/Ig-␤ heterodimer, a part of the B-cell receptor ■ Poly-Ig receptor, which contributes the secretory part of secretory IgA and IgM ■ T-cell receptor ■ T-cell accent proteins, together with CD2, CD4, CD8, CD28, and the ␥, ␦, and ␧ chains of CD3 ■ type I and sophistication II MHC molecules ■ ␤2-microglobulin, an invariant protein linked to classification I MHC molecules ■ a number of cell-adhesion molecules, together with VCAM-1, ICAM-1, ICAM-2, and LFA-3 ■ Platelet-derived progress issue quite a few different proteins, a few of them mentioned in different chapters, additionally belong to the immunoglobulin superfamily. X-ray crystallographic research has no longer been entire for all contributors of the immunoglobulin superfamily. however, the first amino acid series of those proteins means that all of them comprise the common immunoglobulin-fold area. in particular, all contributors of the immunoglobulin superfamily include no less than a number of stretches of approximately one hundred ten amino acids, in a position to association 8536d_ch04_076-104 9/5/02 6:19 AM web page ninety eight mac76 mac76:385 Goldsby et al. /Immunology5e: ninety eight iteration of B-Cell and T-Cell Responses half II Immunoglobulin (IgM) V S S V S S S S S S S S S C S C V S S V S S S S S S C C C S S S S C C S S S S C S S S S C MHC molecules T–cell receptor CHO Ig-α/ Ig-β heterodimer C S S S S C C V S S S S type I category II α β V S S C S S S S C S S S S C S S S S C SS β2 microglobulin C S S S S C Adhesion molecules VCAM-1 S S C Poly- Ig receptor S S C T–cell accent proteins ICAM-1 V S S V C S S C S S V S S γ δ ε S S S S S S V V C C C C V CD8 V S S S S C S S CD3 CD2 S S C CD4 S S S S V C S S S S S S S S C S S C S S C S S ICAM-2 C S S C S S C S S C C S S C S S C S S C C S S LFA–3 S S S S determine 4-20 a few individuals of the immunoglobulin superfamily, a gaggle of structurally comparable, often membrane-bound glycopro- teins. In all instances proven right here with the exception of ␤2-microglobulin, the carboxyl-terminal finish of the molecule is anchored within the membrane. into pleated sheets of antiparallel ␤ strands, often with an invariant intrachain disulfide bond that closes a loop spanning 50–70 residues. so much participants of the immunoglobulin superfamily can't bind antigen. hence, the attribute Ig-fold constitution present in such a lot of membrane proteins should have a few functionality except antigen binding.

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