Download e-book for iPad: ADME and Translational Pharmacokinetics / Pharmacodynamics by Honghui Zhou,Frank-Peter Theil

By Honghui Zhou,Frank-Peter Theil

With an emphasis at the primary and useful elements of ADME for healing proteins, this ebook is helping readers strategize, plan and enforce translational learn for biologic drugs.

• Details state-of-the-art ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs
• Combines theoretical with functional features of ADME in biologic drug discovery and improvement and compares innovator biologics with biosimilar biologics and small molecules with biologics,  giving a lessons-learned point of view
• Includes case stories approximately leveraging ADME to enhance biologics drug improvement for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines
• Presents regulatory expectancies and views for constructing biologic medicinal drugs in united states, ecu, and Japan
• Provides mechanistic perception into biodistribution and target-driven pharmacokinetics in very important websites of motion comparable to tumors and the brain

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ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins: Applications in Drug Discovery and Development by Honghui Zhou,Frank-Peter Theil


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